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KMID : 0369819910210020079
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Jorunal of Korean Pharmaceutical Sciences
1991 Volume.21 No. 2 p.79 ~ p.84
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Determination of Vitamin B12 by Agar Diffusion Method
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이성호/Lee SH
조진성/송영준/Cho CS/Song YJ
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Abstract
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The agar diffustion method using Escherichia coli was investigated for determination of Vitamin Bl2 instead of turbidimetric method using Lactobacillus leichannii (USP XXII method). The turbidimetric method is difficult to control the test organism and it has complicated procedure. From this study, it was found that the agar diffusion method on the determination of Vitamin B12 in pharamaceutical preparation is simple and convenient as compared with turbidimetric method. Also we found that the coefficient of variation in reproducibility and the standard error in recovery were 2.18% and 1.83%, respectively.
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KEYWORD
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Agar diffusion method, Vitamin B12, Escherichia coli
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